Why is Zofran prescribed?

Zofran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, anesthesia, and surgery. Ondansetron is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Zofran be used?

Zofran comes as a tablet and in an injectable form. The tablets may be taken with or without food. The first dose of Ondansetron usually is taken in a hospital or clinic 30 minutes before chemotherapy is begun. The second dose is taken 4 hours after the first dose, and the third dose is taken 8 hours after the first dose. Your doctor also may want you take one tablet every 8 hours for 1 or 2 days after chemotherapy. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Ondansetron exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Ondansetron injections are given by qualified health care professionals.

What special precautions should I follow?

Before taking Zofran,

• tell your doctor and pharmacist if you are allergic to Ondansetron, dolasetron (Anzemet), granisetron (Kytril), or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
• tell your doctor if you have or have ever had liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Ondansetron, call your doctor.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Zofran cause?

Although side effects from Zofran are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea
• headache
• constipation
• rash
• lightheadedness
• dry mouth
• drowsiness

If you experience either of the following symptoms, call your doctor immediately:

• difficulty breathing
• chest pain

What storage conditions are needed for Zofran?

Keep Ondansetron in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?

Keep all appointments with your doctor. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.